Research grants

Researchers at Royal Perth Hospital are involved with a number of research projects through funding from the Australian Research Council (ARC) and the National Health and Medical Research Council (NHMRC).

2017 Medical Research Foundation (MRF) grants

Hospital recipients

Mr Leon Brownrigg
Cell and Tissue Therapies WA

Establishment, Manufacture and Pre-clinical Evaluation of Chimeric Antigen Receptor (CAR) T-cells for Immunotherapy

Dr Hun Chuah
Department of Haematology

Ultra-Sensitive Genetic Monitoring of Acute Myeloid Leukaemia: From “Morphology to Mutation”

A/Professor Christopher Etherton-Beer
Department of Geriatric Medicine

A tailored music therapy and real-time biofeedback mobile phone app to promote motor rehabilitation following stroke

Professor Martyn French
Department Clinical Immunology

Combined cellular and humoral HIV-1 Gag-specific immune responses in the control of HIV-1 infection

Mr Alex Hayes
Department of Medical Engineering and Physics

Evaluation of additive manufacturing as an alternative to cadaveric bone for use in biomechanical implant testing

Dr Alan Kop
Department of Medical Engineering and Physics

Investigation and evaluation of 3D printed tissue engineered bone scaffolds inoculated with adult mesenchymal stem cell spheroids

A/Professor Doug McKitrick
Department of Geriatric Medicine

Does Cerebellar Transcranial Direct Current Stimulation Offer Improved Efficacy for Non-Invasive Brain Stimulation Therapy in Neurological Rehabilitation?

Dr Jeremy Parry
Department of Anatomical Pathology

Novel drivers of progression and treatment resistance in breast cancer

A/Professor Marian Sturm
Cell and Tissue Therapies WA

Expansion of Cord Blood Stem Cell Grafts using Mesenchymal Stromal Cells

Dr Andrew Toner
Department of Anaesthesia and Pain Medicine

Perioperative ADministration of Dexamethasone and Infection [PADDI] – Baroreflex sensitivity sub-study

UWA recipients

Professor Anne Barden
School of Medicine and Pharmacology

Effects of weight loss and n-3 fatty acid supplementation on resolution of inflammation in patients at risk of cardiovascular disease

Dr Catherine Bondonno
School of Medicine and Pharmacology

Increased production of short chain fatty acids by the gut microbiome improves vascular health

Dr Erika Bosio
Centre for Clinical Research In Emergency Medicine

Does the early microRNA profile of stroke have diagnostic potential?

Dr Gemma Cadby
Centre for Genetic Origins of Health and Disease

Understanding the genetics of mesothelioma susceptibility and Prognosis

Dr Dick Chan
School of Medicine and Pharmacology

Effect of Omega-3 Fatty Acid Supplementation on Postprandial Lipoprotein(a) Transport in Subjects at High Risk of Cardiovascular Disease

A/Professor Kay Cox
School of Medicine and Pharmacology

Can a 6-month physical activity intervention in individuals at risk of Alzheimer’s disease impact on cognition, physical activity, mental health, quality of like and utilisation of health services in the long-term?

Dr Sonia Fernandez
School of Pathology and Laboratory Medicine

The effects of IFN-α on B cells and the induction of humoral immune responses in HIV disease

Dr Dagmara Hering
Dobney Hypertension Centre

Is Chemoreflex Sensitivity a Major Contributor to Sympathetic Activation in Chronic Kidney Disease?

Dr Jeanie Leong
Department of Respiratory and Sleep Medicine

Towards improving integration between specialist and primary care for people diagnosed with lung cancer

Dr Stephen Macdonald
Centre for Clinical Research in Emergency Medicine

The role of Resistin in endothelial cell activation in human sepsis

Dr Vance Matthews
School of Medicine and Pharmacology

Determining the impact of renal or hepatic denervation on insulin resistance and liver injury

Professor Vera Morgan
School of Psychiatry and Clinical Neurosciences

Developmental lifecourse trajectories and schizophrenia: Clinical validation of register-derived constructs

Professor Markus Schlaich
Dobney Hypertension Centre

Role of sympathetic nervous system activation in fatty liver disease

Dr Lisa Smart
Centre for Clinical Research in Emergency Medicine

The effect of 4% succinylated gelatine on acute kidney injury in patients with critical illness

Dr Jong Song
Centre for Genetic Origins of Health and Disease

Molecular mechanisms of preterm birth induced childhood asthma

Dr Jennifer Stone
Centre for Genetic Origins of Health and Disease

Mammographic density in families with high-risk of breast cancer

Dr Dino Bee Aik Tan
School of Medicine and Pharmacology

Characterisation of bronchoalveolar lavage fluid-derived exosomes as a target for diagnosis and new treatment strategies for COPD

Dr Natalie Ward
School of Medicine and Pharmacology

Dietary flavonoids and fibre: synergistic beneficial effects on the development of atherosclerosis

Associate Professor Guicheng Zhang
Centre for Genetic Origins of Health and Disease

Using whole genome sequencing to identify pathogenic copy number variants in children with congenital heart defects

2016 Medical Research Foundation (MRF) grants

Hospital recipients

Associate Professor Damon Bell

Neuropsychological and neurophysiological indicators of brain impairment in adults with phenylketonuria (PKU)

Clinical Professor John Burnett

Development of a clinical registry for the management of abetalipoproteinaemia and familial hypobetalipoproteinaemia

Dr Melita Cirillo

Mesenchymal Stromal Cell (MSC) Immunological Therapy for Patients with Myelodysplastic Syndrome

Associate Professor Christopher Etherton Beer

Tops: tDSC to optimise participation in stroke rehabilitation – a sham controlled cross over study

Dr Meg Harrold

Frailty in ICU trauma patients: a prospective observational study

Clinical Professor Graham Hillis

The Low Dose Colchicine After Acute Myocardial Infraction study

Associate Professor Kwok Ming Ho

Preventing venous thromboembolism in critically ill or injured patients using advanced laboratory tests a pilot exploratory study

Dr ALan Kop

Investigation and evaulation of 3D printed tissue engineered bone scaffolds inoculated with adult mesenchymal stem cell spheriods and culured in the RPH bioreactor

Clinical Professor Phillipa Lamont

Conversation of a PC based mitochondrial disease registry to an open source, Australia - wide patient registry framework

Dr Jacqui Saw

Prognosis after first - ever seizure a prospective hospital - based study

Dr Marian Sturm

Expansion of Cord Blood Stem Cell Grafts using Mesenchymal Stromal Cells

Clinical Associate Professor Donna

A feasibility study to evaluate whether the addition of Contrast Enhanced Mammography to tomosynthesis for diagnostic assessment of non-calcified lesions can improve diagnostic work-up

UWA recipients

Professor Anne Barden

The effect of alcohol on resolution of inflammation in healthy men and patients with Type 2 diabetes

Professor Kevin Croft

Dietary nitrate benefical effects on obesity and development of metabolic syndrome

Dr Katrina Ellis

Investigation of Polygenic Familial Hypercholestrolaemia and Related Lipid Disorders

Dr Dagmara Hering

Effect of renal denveration on sympathetic and neural reflex mechanisms in patients with resistant hypertension

Dr Vance Matthews

Potential role of the sympathetic nervious system in regulation of the sodium glucose co-transporter-2 in Amerindians

Dr Esther Ooi

Lipoprotein (a) a new risk factor of premature coronary artery disease in an Australian population

Dr Dino Tan

Novel approaches to treating bacterial infection in COPD by blocking inhibitory T-cell receptors

Dr Sarah Ward

Identification of gene-environment interactions associated with multiple primary melanoma

Dr Andrew Woo

Functional examination of the ZBP family of transcription factors in cancer metastasis

2014 Diabetes Grants

Dr Johnathan Hodgson

Effects of Lupin-containing foods on glycaemic control and blood pressure in Type 2 Diabetes.

Winthrop Prof Carl Schultz

A double blind randomized placebo controlled 2x2 factorial trial of the effect of vitamin K and colchicine on vascular calcification activity in subject with diabetes mellitus: The ViKCoVaC Diabetes Study.

A/Prof Seng Khee Gan

Genetic and metabolomic predictors of outcomes and complications of diabetes.

A/Prof Gerard Chew

Comparison of the effect of an early transition to oral versus prolonged intravenous antibiotic treatment strategy on clinical outcomes in diabetic foot infections with osteomyelitis: a randomised open-label pilot study.

Clinical Prof Thomas

The perioperative administration of Dexamethasone and blood glucose concentrations – The PADDAG trial.

Australian Research Council (ARC)

2013 Discovery Projects

Associate Professor O Rackham
Associate Professor A Filipovska

Sythetic regulators of gene expression

National Health and Medical Research Council (NHMRC)

2013 Project Grants

Associate Professor J Hamzah

Targeting inflammatory macrophages and blood vessels in atheroslerotic plaques for imaging and therapy

Dr E Ooi
Professor H Barrett
Professor G Watts
Dr D Chan

Lipoprotein metabolism in subjects at high risk of cardiovascular disease

Professor R Ganss

Molecular mechanisms in pregnancy-induced hypertension

Professor O Almeida
Professor L Flicker

An Australasian, multi-centre, randomized, double-blind, placebo-controlled trial of the efficacy of fluoxetine in improving functional recovery after acute stroke

Associate Professor R Huang
Emeritus Professor L Beilin
Professor T Mori

The cyle of obesity: Two generations of a pregnancy cohort to investigate obesity epigenetics

Professor L Flicker

Trajectories of circulating testosterone and estradiol and implications for the health of aging men

Professor A Jablensky
Professor V Morgan

Schizophrenia under the genomic lens: next generation sequencing of Western Australian families with schizophrenia

Professor J Hodgson
Professor K Croft
Associate Professor R Woodman
Dr N Ward

Nitrate: studies of metabolism and effects on blood pressure

Dr J Rankin

Long-term use and cost-effectiveness of secondary preventation medications for heart disease in Western Australian seniors

Dr D Nolan

Narrow band UVB phototherapy for patients with clinically isolated syndrome

Professor P Price
Associate Professor C Witt
Professor A Irish
Associate Professor R Allcock
Dr S Lee

Do NK cells limit the long-term burden of CMV in older Australians and transplant recipients?

Professor G Morahan

Discovery of genes that protect against tau-induced neuropathology

Professor P Leedman

Role of SLIRP in colorectal cancer

Associate Professor A Filipovska

Research Fellowships (Senior Research Fellowship B)

Professor S Webb

Platform for European preparedness against emerging epidemics