Research grants

Researchers at Royal Perth Hospital are involved with a number of research projects through funding from the Australian Research Council (ARC) and the National Health and Medical Research Council (NHMRC). 

2017 Medical Research Foundation (MRF) grants

Hospital recipients

Mr Leon Brownrigg, Cell and Tissue Therapies WA
Establishment, Manufacture and Pre-clinical Evaluation of
Chimeric Antigen Receptor (CAR) T-cells for Immunotherapy

Dr Hun Chuah, Department of Haematology
Ultra-Sensitive Genetic Monitoring of Acute Myeloid Leukaemia:
From “Morphology to Mutation”

A/Professor Christopher Etherton-Beer, Department of Geriatric Medicine
A tailored music therapy and real-time biofeedback mobile 
phone app to promote motor rehabilitation following stroke

Professor Martyn French, Department Clinical Immunology

Combined cellular and humoral HIV-1 Gag-specific immune
responses in the control of HIV-1 infection

Mr Alex Hayes, Department of Medical Engineering and Physics
Evaluation of additive manufacturing as an alternative to
cadaveric bone for use in biomechanical implant testing

Dr Alan Kop, Department of Medical Engineering and Physics
Investigation and evaluation of 3D printed tissue engineered 
Bone scaffolds inoculated with adult mesenchymal stem cell

A/Professor Doug McKitrick, Department of Geriatric Medicine
Does Cerebellar Transcranial Direct Current Stimulation Offer 
Improved Efficacy for Non-Invasive Brain Stimulation Therapy in 
Neurological Rehabilitation?

Dr Jeremy Parry, Department of Anatomical Pathology

Novel drivers of progression and treatment resistance in
breast cancer

A/Professor Marian Sturm, Cell and Tissue Therapies WA
Expansion of Cord Blood Stem Cell Grafts using Mesenchymal
Stromal Cells

Dr Andrew Toner, Department of Anaesthesia and Pain Medicine
Perioperative ADministration of Dexamethasone and Infection
[PADDI] – Baroreflex sensitivity sub-study

UWA recipients

Professor Anne Barden, School of Medicine and Pharmacology
Effects of weight loss and n-3 fatty acid supplementation on
Resolution of inflammation in patients at risk of cardiovascular

Dr Catherine Bondonno, School of Medicine and Pharmacology
Increased production of short chain fatty acids by the gut
microbiome improves vascular health

Dr Erika Bosio,
Centre for Clinical Research In Emergency Medicine

Does the early microRNA profile of stroke have diagnostic potential?

Dr Gemma Cadby, Centre for Genetic Origins of Health and Disease
Understanding the genetics of mesothelioma susceptibility and

Dr Dick Chan, School of Medicine and Pharmacology
Effect of Omega-3 Fatty Acid Supplementation on Postprandial
Lipoprotein(a) Transport in Subjects at High Risk of Cardiovascular

A/Professor Kay Cox, School of Medicine and Pharmacology
Can a 6-month physical activity intervention in individuals at risk
of Alzheimer’s disease impact on cognition, physical activity, 
mental health, quality of like and utilisation of health services
in the long-term?

Dr Sonia Fernandez, School of Pathology and Laboratory Medicine
The effects of IFN-α on B cells and the induction of humoral
immune responses in HIV disease

Dr Dagmara Hering, Dobney Hypertension Centre
Is Chemoreflex Sensitivity a Major Contributor to Sympathetic
Activation in Chronic Kidney Disease?

Dr Jeanie Leong, Department of Respiratory and Sleep Medicine
Towards improving integration between specialist and primary
care for people diagnosed with lung cancer

Dr Stephen Macdonald,
Centre for Clinical Research in Emergency Medicine

The role of Resistin in endothelial cell activation in human

Dr Vance Matthews, School of Medicine and Pharmacology
Determining the impact of renal or hepatic denervation on insulin
resistance and liver injury

Professor Vera Morgan,
School of Psychiatry and Clinical Neurosciences

Developmental lifecourse trajectories and schizophrenia:
Clinical validation of register-derived constructs

Professor Markus Schlaich, Dobney Hypertension Centre
Role of sympathetic nervous system activation in fatty liver disease

Dr Lisa Smart,
Centre for Clinical Research in Emergency Medicine

The effect of 4% succinylated gelatine on acute kidney injury in
patients with critical illness

Dr Jong Song, Centre for Genetic Origins of Health and Disease
Molecular mechanisms of preterm birth induced childhood asthma

Dr Jennifer Stone,
Centre for Genetic Origins of Health and Disease

Mammographic density in families with high-risk of breast cancer

Dr Dino Bee Aik Tan, School of Medicine and Pharmacology
Characterisation of bronchoalveolar lavage fluid-derived exosomes
as a target for diagnosis and new treatment strategies for COPD

Dr Natalie Ward, School of Medicine and Pharmacology
Dietary flavonoids and fibre: synergistic beneficial effects on the
development of atherosclerosis

Associate Professor Guicheng Zhang,
Centre for Genetic Origins of Health and Disease

Using whole genome sequencing to identify pathogenic copy
number variants in children with congenital heart defects

2016 Medical Research Foundation (MRF) grants

Hospital recipients

 Associate Professor Damon Bell                                                         

Neuropsychological and neurophysiological indicators of brain impairment in adults with phenylketonuria (PKU)

Clinical Professor John Burnett

Development of a clinical registry for the management of abetalipoproteinaemia and familial hypobetalipoproteinaemia

Dr Melita Cirillo

Mesenchymal Stromal Cell (MSC) Immunological Therapy for Patients with Myelodysplastic Syndrome

Associate Professor Christopher Etherton Beer

Tops: tDSC to optimise participation in stroke rehabilitation – a sham controlled cross over study

Dr Meg Harrold

Frailty in ICU trauma patients: a prospective observational study

Clinical Professor Graham Hillis

The Low Dose Colchicine After Acute Myocardial Infraction study

Associate Professor Kwok Ming Ho

Preventing venous thromboembolism in critically ill or injured patients using advanced laboratory tests a pilot exploratory study

Dr ALan Kop

Investigation and evaulation of 3D printed tissue engineered bone scaffolds inoculated with adult mesenchymal stem cell spheriods and culured in the RPH bioreactor

Clinical Professor Phillipa Lamont

Conversation of a PC based mitochondrial disease registry to an open source, Australia - wide patient registry framework

Dr Jacqui Saw

Prognosis after first - ever seizure a prospective hospital - based study

Dr Marian Sturm

Expansion of Cord Blood Stem Cell Grafts using Mesenchymal Stromal Cells

Clinical Associate Professor Donna

A feasibility study to evaluate whether the addition of Contrast Enhanced Mammography to tomosynthesis for diagnostic assessment of non-calcified lesions can improve diagnostic work-up

UWA recipients

Professor Anne Barden                                                   The effect of alcohol on resolution of inflammation in healthy men and patients with Type 2 diabetes

Professor Kevin Croft

Dietary nitrate benefical effects on obesity and development of metabolic syndrome

Dr Katrina Ellis

 Investigation of Polygenic Familial Hypercholestrolaemia and Related Lipid Disorders

Dr Dagmara Hering

Effect of renal denveration on sympathetic and neural reflex mechanisms in patients with resistant hypertension

Dr Vance Matthews

Potential role of the sympathetic nervious system in regulation of the sodium glucose co-transporter-2 in Amerindians

Dr Esther Ooi             

Lipoprotein (a) a new risk factor of premature coronary artery disease in an Australian population

Dr Dino Tan  

Novel approaches to treating bacterial infection in COPD by blocking inhibitory T-cell receptors

 Dr Sarah Ward

Identification of gene-environment interactions associated with multiple primary melanoma

 Dr Andrew Woo                                               

Functional examination of the ZBP family of transcription factors in cancer metastasis

2014 Diabetes Grants 

Dr Johnathan Hodgson                                                             Effects of Lupin-containing foods on glycaemic control and blood pressure in Type 2 Diabetes.
Winthrop Prof Carl Schultz              A double blind randomized placebo controlled 2x2 factorial trial of the effect of vitamin K and colchicine on vascular calcification activity in subject with diabetes mellitus: The ViKCoVaC Diabetes Study.
A/Prof Seng Khee Gan                      Genetic and metabolomic predictors of outcomes and complications of diabetes.
A/Prof Gerard Chew Comparison of the effect of an early transition to oral versus prolonged intravenous antibiotic treatment strategy on clinical outcomes in diabetic foot infections with osteomyelitis: a randomised open-label pilot study.
Clinical Prof Thomas Cor                            The perioperative administration of Dexamethasone and blood glucose concentrations – The PADDAG trial.

Australian Research Council (ARC)

2013 Discovery Projects

Sythetic regulators of gene expression                       Associate Professor O Rackham
Associate Professor A Filipovska

National Health and Medical Research Council (NHMRC)

2013 Project Grants

Targeting inflammatory macrophages and blood vessels in                                      
atheroslerotic plaques for imaging and therapy

Associate Professor J Hamzah

Lipoprotein metabolism in subjects at high risk of
cardiovascular disease

Dr E Ooi
Professor H Barrett
Professor G Watts
Dr D Chan
Molecular mechanisms in pregnancy-induced hypertension
Professor R Ganss
An Australasian, multi-centre, randomized, double-blind,
placebo-controlled trial of the efficacy of fluoxetine in improving
functional recovery after acute stroke
Professor O Almeida
Professor L Flicker

The cyle of obesity: Two generations of a pregnancy cohort
to investigate obesity epigenetics

Associate Professor R Huang
Emeritus Professor L Beilin
Professor T Mori
Trajectories of circulating testosterone and estradiol and
implications for the health of aging men
Professor L Flicker

Schizophrenia under the genomic lens: next generation
sequencing of Western Australian families with schizophrenia
Professor A Jablensky
Professor V Morgan
Nitrate: studies of metabolism and effects on blood pressure

Professor J Hodgson
Professor K Croft
Associate Professor R Woodman
Dr N Ward
Long-term use and cost-effectiveness of secondary
preventation medications for heart disease
in Western Australian seniors
Dr J Rankin

Narrow band UVB phototherapy for patients with clinically
isolated syndrome
Dr D Nolan

Do NK cells limit the long-term burden of CMV in older
Australians and transplant recipients?

Professor P Price
Associate Professor C Witt
Professor A Irish
Associate Professor R Allcock
Dr S Lee
Discovery of genes that protect against tau-induced neuropathology
Professor G Morahan
Role of SLIRP in colorectal cancer
Professor P Leedman
Research Fellowships (Senior Research Fellowship B)
Associate Professor A Filipovska
Platform for European preparedness against emerging epidemics
Professor S Webb